Calpains: Markers of tumor aggressiveness?

TITLE : Hyperpolarized 13 C MR markers of renal tumor aggressiveness

AWARD NUMBER: W81XWH-12-1-0328 TITLE: Hyperpolarized 13C MR Markers of Renal Tumor Aggressiveness

Renal cell carcinomas (RCC) are a heterogeneous group of tumors with a wide range of aggressiveness. Noninvasive methods to confidently predict the tumor biologic behavior and select appropriate treatment are lacking. Here, we investigate the dynamic metabolic flux in living RCC cells using hyperpolarized C-pyruvate magnetic resonance spectroscopy (MRS) combined with a bioreactor platform and i...

Photonic Breast Tomography and Tumor Aggressiveness Assessment

Time reversal optical tomography (TROT) approach is used to detect and locate absorptive targets embedded in a highly scattering turbid medium to assess its potential in breast cancer detection. TROT experimental arrangement uses multisource probing and multi-detector signal acquisition and Multiple-Signal-Classification (MUSIC) algorithm for target location retrieval. Light transport from mult...

CD44 enhances tumor aggressiveness by promoting tumor cell plasticity

Aggressive tumor cells can obtain the ability to transdifferentiate into cells with endothelial features and thus form vasculogenic networks. This phenomenon, called vasculogenic mimicry (VM), is associated with increased tumor malignancy and poor clinical outcome. To identify novel key molecules implicated in the process of vasculogenic mimicry, microarray analysis was performed to compare gen...

Tumor markers

Searching for early signs of cancer enabling a quick therapeutic and diagnostic intervention is the main concern of all clinicians. As such, tumor markers can be a precious help. In a short revision concerning this theme, the authors present a practical definition and classification of tumor markers, giving more importance to serological markers as these are more easily obtained. Despite their ...